Work Package 4

Design, preparation and characterization of  new glasses suitable for medical applications

Development of glass-based biomaterials for oncology (i.e. ferrimagnetic glass-ceramics for hyperthermia), drug release (bioactive glasses and microcellular ceramics) and bone substitution (i.e. glass-ceramic macroporous scaffolds, porous wollastonite-apatite ceramics from filled preceramic polymers) and arthroprosthesis (i.e. glass and composite bioactive coatings).

An integrated approach to the application of bioactive glasses in the biomedical field, from materials development to in vitro tests, will be pursued, including also a comprehensive comparison with available biomaterials to highlight the advantages (and possible disadvantages) of bioactive glasses in the different selected applications.

WORK PACKAGE LEADER: ERLANGEN

Description of work

T4.1 Glass-based biomaterials as drug release systems (Task leader ERLAGEN, other participants POLITO, NANOFORCE)

Design, development and characterisation of  bioactive glasses and microcellular ceramics for drug release.

T4.2 Bioactive glasses and composites for bone substitution (Task leader POLITO other participants ERLANGEN, NANOFORCE, UNIPD)

Design, development and characterisation of  glass-ceramics for bone substitution (i.e. glass-ceramic macroporous scaffolds, porous wollastonite-apatite ceramics from filled preceramic polymers).

T 4.3 Glass and bioactive composite coatings for orthopaedic implants and devices (Task leader IPM, other participants COLOR, POLITO, NANOFORCE, ERLANGEN, UNIPD)

Design, development and characterisation of glass and composite bioactive coatings  for arthroprosthesis

T4.4 Bioactive glass based porous scaffolds for tissue engineering (Task leader ERLAGEN, other participants POLITO, NANOFORCE, UNIPD)

The aim of this task is to develop a new family of novel silicate glass compositions for glass based porous scaffolds  for tissue engineering. The main characteristic of the glasses to be developed is their enhanced bioactivity, which makes them Class A bioactive materials as opposed to calcium phosphate glasses or hydroxyapatite (class B materials).

Recruited researchers to be involved (ESR= early stage researcher, ER= experienced researcher):

ESR3 will “Design and develop glass based materials for bone substitution” and will be involved in T4.2 and T4.4.

ESR6 will “Design and development of glass-based biomaterials as drug release systems” and will be involved in T4.1

ESR7 will “Design and develop bioactive glass based scaffolds  for tissue engineering” and will be involved in T4.4.

ESR10 will study “Glass and glass-ceramic components” and will be also involved in T4.2

ESR12 will “Characterise glass and composite bioactive coatings (for arthroprosthesis)” and will be involved in T4.3.

ESR15 will “Design and prepare bioactive glass based coating for medical devices” and will be involved in T4.3

ER6 will study “Bioactive glasses and composites for bone substitution prepared by Spark Plasma Sintering” and will be involved in T4.2.

Glass-ceramic scaffold (Politecnico di Torino)

Hydroxyapatite grown on a bioactive glass-ceramic scaffold trabecula (Politecnico di Torino)